Villa Crypt

The most obvious change I made to her face are her eyes. In her original N64 appearance the white eyes with no irides are pretty effective, but I feel there's no way I can do justice to that look if I keep them white in high resolution. I went with bloodshot eyes instead.
Other than that I simply added color to her face with some blue and purple highlights.

It is a large part of the storyline early on that villagers (especially children) have been kidnapped and/or killed. Therefore I thought it made more sense to have her look like an actual villager instead of a random maiden in a gown. I actually used the peasant girls from The Witcher as inspiration for her new outfit.
Castle Center
This one is semi-new though (as in, not yet in the currently available pack)
In the Castle Center the female crypt vampire returns as a regular enemy (although it seems to be random which vampires spawn). She is basically a palette swap of her previous iteration, so in exactly the same fashion I simply changed the hue of her crypt appearance.

I thought her original appearance looked way too bland. Compared to the other possible vampires that spawn there, she looks gray. I thought a dark red dress would look way better on her.
Also, she's a complete pain to screencap properly.

Face up he... wait what?

This one is the best I could manage.